skin curriculum

Original Article : Prevalence of chronic hand eczema in adults: a cross-sectional survey of over 60 000 respondents from the general population of Canada, France, Germany, Italy, Spain and the UK What are the key takeaways of this article? A new, multinational cross-sectional study published in British Journal of Dermatology assessing the prevalence of chronic hand eczema (CHE) in adults found an annual prevalence of 4.7% (95% CI 4.6–4.9) among 60,131 participants who self-re

Original Article : Disparities in Acral Lentiginous Melanoma: Racial Factors Beyond Delayed Diagnosis What are the key takeaways of this article? This population-based study aimed to investigate whether racial disparities in acral lentiginous melanoma (ALM) outcomes are truly due to delayed diagnosis, as commonly assumed. Using data from the Surveillance, Epidemiology, and End Results (SEER) Program, the researchers analyzed melanoma severity at diagnosis and melanoma-specifi

Original Article : Dupilumab in Patients With Chronic Spontaneous Urticaria Phase 3 LIBERTY-CSU CUPID Randomized Clinical Trials What are the key takeaways of this article? Chronic spontaneous urticaria (CSU) is a condition characterized by recurrent hives, angioedema, and intense itching that persist for more than 6 weeks without a clear trigger. Despite treatment with antihistamines, many patients continue to experience persistent symptoms, significantly impairing sleep, da

Original Article : Resminostat for maintenance treatment in patients with advanced-stage mycosis fungoides or Sézary syndrome: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial What are the key takeaways of this article? Advanced-stage mycosis fungoides (MF) and Sézary syndrome (SS) are aggressive forms of cutaneous T-cell lymphoma (CTCL) characterized by frequent relapses, progressive disease, and limited durable treatment options. While several syst

Original Article : Isotretinoin Treatment in Adolescence and Adult Height What are the key takeaways of this article? Isotretinoin is an effective treatment for moderate-to-severe acne, but concerns have persisted regarding its potential effects on skeletal development and linear growth during adolescence. Because isotretinoin is a retinoid and rare case reports have suggested a link to premature closure of growth plates, questions remain about whether treatment during adoles

Original Article : Clinical spectrum and quality of life burden of vulvar lichenoid dermatoses: a cross-sectional study of 1177 patients What are the key takeaways of this article? Vulvar lichenoid dermatoses are a group of chronic inflammatory conditions affecting the vulvar skin and mucosa. Vulvar lichen sclerosis (VLS), vulvar lichen simplex chronicus (VLSC), and erosive vulvar lichen planus (EVLP) are the most common types. These conditions are frequently misdiagnosed, an

Original Article : Adjuvant Cemiplimab or Placebo in High-Risk Cutaneous Squamous-Cell Carcinoma (C-POST Trial) What are the key takeaways of this article? Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer. Surgery remains a cornerstone treatment for many patients, but those with high-risk features such as large or multiple involved lymph nodes, perineural invasion, bone invasion, or locally recurrent tumor face a recurrence rate around 45% even

Original Article : Acne Incidence and Severity in Transgender Individuals What are the key takeaways of this article? This large retrospective cohort study evaluated the incidence of acne among transgender individuals undergoing gender-affirming hormone therapy (GAHT), compared with matched cisgender controls. Using electronic health record data from over 280,000 patients without baseline acne across multiple health systems, the study provides robust, population-level insight

Original Article : Effectiveness of Systemic Treatments for Atopic Dermatitis in the Head-and-Neck-Area: A Systematic Review and Meta-analysis What are the key takeaways of this article? Atopic dermatitis (AD) involving the head and neck (H&N) is a common and particularly burdensome presentation of disease, often associated with reduced quality of life, visible skin changes, and treatment challenges due to the sensitivity of the area. Although systemic therapies are increasin

Original Article : Molecular effects of indoor tanning What are the key takeaways of this article? Indoor tanning has been consistently associated with an elevated risk of melanoma, the most serious form of skin cancer. Despite longstanding public health warnings, the indoor tanning industry has maintained that tanning beds are comparable in risk to natural sunlight, often citing a lack of definitive molecular evidence. This retrospective observational study with case-control

Original Article : A national cohort study of melanoma BRAF status, testing patterns, patient and tumour characteristics, treatment and survival in England from 2016 to 2021 What are the key takeaways of this article? Melanoma is an aggressive skin cancer in which mutations in the BRAF gene play a critical role in prognosis and treatment selection. BRAF mutation status predicts response to targeted therapy and informs immunotherapy strategies. However, inconsistent molecular

Original Article : Glucagon-like peptide-1 receptor agonist medications and hair loss: A retrospective cohort study What are the key takeaways of this article? Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have gained widespread popularity for their use in the management of type 2 diabetes mellitus and obesity. Within dermatology, increasing discussion has been directed toward the effects of GLP-1RA use on hair health. Proposed mechanisms are currently conflicting. Som

Original Article : Human Papillomavirus Vaccination and Actinic Keratosis Burden: The VAXAK Randomized Clinical Trial What are the key takeaways of this article? Actinic keratoses (AKs) are the most common precancerous skin lesions in fair-skinned populations, representing a significant public health burden due to their potential progression to squamous cell carcinoma and the substantial costs associated with their management. Recent evidence has suggested a possible associat

Original Article : Upadacitinib for the Treatment of Pyoderma Gangrenosum: A Literature Review What are the key takeaways of this article? Pyoderma gangrenosum (PG) is a rare, noninfectious neutrophilic dermatosis characterized by painful nodules that rapidly progress to ulceration. It is often associated with systemic inflammatory conditions such as inflammatory bowel disease and rheumatoid arthritis, and can be difficult to treat due to its refractory nature. Increasing evi

Original Article : Phase 3 Trial of Nemolizumab in Patients with Prurigo Nodularis What are the key takeaways of this article? Prurigo nodularis (PN) is a chronic skin condition marked by severe, relentless itching and hard bumps caused by repeated scratching. Many patients describe it simply as “chronic itch” or are told they have “neurodermatitis.” PN is not the same as atopic dermatitis (eczema), although the two can overlap. In PN, itch is the central problem, often leadi

Original Article : Skin Barrier Dysfunction in Acne Vulgaris: Pathogenesis and Therapeutic Approaches What are the key takeaways of this article? Acne vulgaris is one of the most common dermatologic conditions worldwide and its pathogenesis is traditionally described by four main processes: increased sebum production, follicular hyperkeratinization, bacterial colonization and proliferation within obstructed follicles, particularly by Cutibacterium acnes , and subsequent immun

Original Article : Understanding Burdens and Barriers to Dermatological Management, and Potential for Virtual Care in Northern and Rural Canadian Indigenous Communities: A National Healthcare Practitioner Cross-Sectional Survey Analysis What are the key takeaways of this article? Northern and Rural Canadian Indigenous communities (NRCIC) face long-standing systemic inequities, mainly rooted in colonial history, geographic isolation, and limited local resources. These factors

Original Article : Risk of Suicide and Psychiatric Disorders Among Isotretinoin Users: A Meta-Analysis What are the key takeaways of this article? This large meta-analysis aimed to clarify whether isotretinoin, a widely used treatment for severe acne, is associated with increased risk of suicide or psychiatric disorders. The study synthesized data from 25 observational studies involving over 1.6 million participants, analyzing both the absolute and relative risks of psychiatr

Original Article : Risk of major adverse cardiovascular events and venous thromboembolic events between patients with psoriasis or psoriatic arthritis on tumor necrosis factor inhibitors, interleukin 17 inhibitors, interleukin 12/23 inhibitors, and interleukin 23 inhibitors: An emulated target trial analysis What are the key takeaways of this article? Psoriasis and psoriatic arthritis, collectively referred to as psoriatic disease, are chronic inflammatory conditions that n

Original Article : Efficacy, safety, and target engagement of dazukibart, an IFNβ specific monoclonal antibody, in adults with...