Is There a Link Between Psoriasis and Breast Cancer?

Original Article: Risk of breast cancer among patients with psoriasis: a systematic review and meta‑analysis

What are the key takeaways of this article?

Psoriasis is a chronic inflammatory skin condition affecting around 125 million people worldwide. It is characterized by the rapid buildup of skin cells, resulting in red, itchy patches. Its exact etiology is mostly unknown and there is currently no cure. The fluctuating nature of the condition often leads to psychological challenges, including depression and a lower quality of life. Psoriasis has emerged as a prominent research area due to its potential association with various health complications, such as cancer. In particular, psoriasis has known associations with several cancer-related risk factors, such as smoking and alcohol consumption, that may serve as possible mechanisms to explain this relationship.

In this study, researchers specifically explored a potential connection between psoriasis and breast cancer. This proposed link may be attributed to reactions induced by minor skin traumas, often occurring during surgery or radiotherapy for psoriasis treatment. The primary focus of recent research has been to answer two crucial questions: Is there an elevated risk of breast cancer in individuals with psoriasis? And, are the risks of breast cancer different depending on the severity of psoriasis, specifically distinguishing between mild and moderate-to-severe cases?

To address these questions, a comprehensive systematic review and meta-analysis were conducted. Researchers scoured PubMed, Cochrane Library, and Embase databases for relevant cohort studies. Utilizing a random-effects model, they performed a meta-analysis to determine the pooled hazard ratio for breast cancer in relation to psoriasis. Subgroup analysis was also carried out, focusing on patients with mild and moderate-to-severe psoriasis.

The results from the random-effects model revealed no statistically significant difference in the incidence of breast cancer between individuals with and without psoriasis. Furthermore, the study showed no significant variance in breast cancer incidence when comparing patients with mild psoriasis to those without the condition. Similarly, no substantial difference was found between patients with moderate-to-severe psoriasis and those without psoriasis. Despite the lack of statistical differences in breast cancer incidence among individuals with psoriasis, the study delves into potential mechanisms linking the two conditions. Psoriasis has been shown to induce poor sleep and mental disorders, both recognized risk factors for breast cancer. 

In summary, while the risk of breast cancer does not appear significantly increased in individuals with psoriasis, regardless of severity, the study highlights the need for continued research. Long-term follow-up studies and assessments of different stages are recommended to ascertain whether psoriasis may serve as a significant and independent predictive factor for the severity and progression of breast cancer. This ongoing exploration promises a deeper understanding of the interplay between psoriasis and cancer. Further studies have the potential to pave the way for more targeted interventions and improved patient outcomes.

Publication Date: January 20th, 2024

Reference: Tung TH, Jiesisibieke ZL, Cheng YH, Chi CC. Risk of breast cancer among patients with psoriasis: a systematic review and meta-analysis. Arch Dermatol Res. 2023 Dec 1;316(1):12. doi: 10.1007/s00403-023-02753-9. PMID: 38038780.

Summary By: Sascha Azoulay